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How to Make 0.1% Chlorine Solution (Healthcare Settings).Emergency Preparedness and Response Capacity Assessment Tool.Information Metrics for Response Leadership.If a person receives two or more discordant laboratory-based NAAT results within a 48-hour period, the person should contact a healthcare provider or the local or state health department for test interpretation and clinical guidance on what steps to take. In cases of discordant test results from different types of tests, results from laboratory-based NAATs should be prioritized over any POC or self-administered test. CDC recommends collecting and testing an upper respiratory specimen, such as nasopharyngeal, nasal mid-turbinate, or anterior nasal, when using NAATs for confirmatory testing. However, saliva specimen quality can be highly variable, which can affect the performance of the test. Saliva is an acceptable specimen type for SARS-CoV-2 testing, and some NAATs have been authorized for use with saliva specimens that provide definitive diagnostic and screening results. If the testing environment does not have the resources or the ability to access laboratory-based NAATs, POC NAATs can also be used for confirmatory testing. If POC NAATs do not deliver presumptive results, they can be used for confirmatory testing. Sensitivity varies by test, but laboratory-based NAATs generally have higher sensitivity than POC tests or self-administered tests.īecause laboratory-based NAATs are considered the most sensitive tests for detecting SARS-CoV-2, they can also be used to confirm the results of lower sensitivity tests, such as POC NAATs or antigen tests. The level of sensitivity for the detection of SARS-CoV-2 genetic material in a specimen also varies depending on the methods and application of the NAAT. Some NAATs are considered rapid tests that are performed at or near the place where the specimen is collected and can provide the result within minutes, whereas the time to complete laboratory-based NAATs ranges from less than an hour to more than a day. Some NAATs can even be self-administered at home or in other non-healthcare locations. NAATs have been authorized for use in different settings, such as in laboratory facilities by trained personnel (laboratory-based) or in point-of-care (POC) settings. The FDA will likely authorize additional NAAT methods in the future. Food and Drug Administration (FDA) for the detection of SARS-CoV-2 have increased. Since the beginning of the COVID-19 pandemic, both the number and types ( methods and technologies ) of NAATs authorized for emergency use by the U.S. Strand displacement amplification (SDA).Clustered regularly interspaced short palindromic repeats (CRISPR).Loop-mediated isothermal amplification (LAMP).Transcription mediated amplification (TMA).Nicking endonuclease amplification reaction (NEAR).Reverse transcription polymerase chain reaction (RT-PCR).NAATs can use many different methods to amplify nucleic acids and detect the virus, including but not limited to: In other words, NAATs can reliably detect small amounts of SARS-CoV-2 and are unlikely to return a false-negative result of SARS-CoV-2. Amplifying those nucleic acids enables NAATs to detect very small amounts of SARS-CoV-2 RNA in a specimen, making these tests highly sensitive for diagnosing COVID-19. The NAAT procedure works by first amplifying – or making many copies of – the virus’s genetic material, if any is present in a person’s specimen. See CDC’s Collecting and Handling of Clinical Specimens for COVID-19 Testing. The type of specimen collected when testing for SARS-CoV-2 is based on the test being performed and the manufacturer’s instructions. NAATs for SARS-CoV-2 test specimens from either the upper or lower respiratory tract. NAATs for SARS-CoV-2 specifically identify the RNA (ribonucleic acid) sequences that comprise the genetic material of the virus.

NAATs detect genetic material (nucleic acids). A Nucleic Acid Amplification Test, or NAAT, is a type of viral diagnostic test for SARS-CoV-2, the virus that causes COVID-19.

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